A SUV hit the school van at the intersection of Route 501 and Michters Road, south of Schaefferstown around 4 p.m. says dispatch.
All the students in the bus and the driver were taken to a local hospital, according to crews at the scene.
There is no word on the extent of anyone's injuries.
Pennsylvania state police are investigating the crash.
Click here to follow Daily Voice Lower Paxton and receive free news updates.